A recent paper in Molecular Systems Biology discusses the use of ontologies to describe complex models. They discuss how depictions of biological systems and pathways have advanced from simple schematics that we all memorized in college to incredibly large and complex dynamic models. This change has taken place due to recent advances in both computers and omic technologies. However, these complex models require semantic descriptions to be widely useful to the scientific community. This paper discusses some of the currently available ontologies used to describe these models.
Courtot M, Juty N, KnÃ¼pfer C, Waltemath D, Zhukova A, DrÃ¤ger A, Dumontier M,
Finney A, Golebiewski M, Hastings J, Hoops S, Keating S, Kell DB, Kerrien S,
Lawson J, Lister A, Lu J, Machne R, Mendes P, Pocock M, Rodriguez N, Villeger A,
Wilkinson DJ, Wimalaratne S, Laibe C, Hucka M, Le NovÃ¨re N. Controlled
vocabularies and semantics in systems biology. Mol Syst Biol. 2011 Oct 25;7:543.
doi: 10.1038/msb.2011.77. PubMed PMID: 22027554.
Integrative methods to study complex biological phenomena
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