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How to reduce in-source decay/dissociation on orbi-trap MS

Posted: Fri May 02, 2014 8:22 am
by zhangcc
Does anyone know how to How to reduce unwanted in-source decay or dissociation on ESI orbi-trap mass spec? There are a couple of voltage parameters: source voltage, capillary voltage, and tube lens voltage. which one should be watched for? There is also an option button for source fragmentation energy(volt), which could be on or off. The default is off. What parameter changes if it was selected? Thanks a lot!

Posted: Mon May 05, 2014 12:07 am
by Kelstrup
Try to decrease S-lens RF and check that the heated capillary is not bent.

My 2 cents.