Comparing distributions in m/z, ret. time and intensity

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Phosphoserine Member
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Comparing distributions in m/z, ret. time and intensity

Postby august » Wed Apr 01, 2015 12:40 pm


I have some data points in the usual m/z, ret.time and intensity planes for two subjects. Is there any way I can compare
the joint distribuions of these m/z, ret.time and intensity for the two subjects. I wish to know if there are differences between distributions within these two subjects.

Is there any multivariate distribution comparison algorithm for doing this?

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E. Coli Lysate Member
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Postby Infinity » Wed Apr 01, 2015 12:51 pm

Do you have an MS/MS scans as well? Then you can use just one of the software solutions for label-free quantification and it will compare intensities of the corresponding peaks between your samples.

Angiotensin Member
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Postby Christopher » Thu Apr 02, 2015 7:39 am

You could possibly use Hardklor for this ( I have not used it in quite some time, so I don't know how well it would work for this.

Ubiquitin Member
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Postby tsbatth » Sat Apr 04, 2015 6:43 am

Seems like you're interested in using accurate mass tags (AMT). If this is for peptide/proteomics samples MaxQuant has a nice feature called match between runs which is basically AMT you can use easily.

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